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This action isdirect and can be restricted to a site by localadministration. Pulmonary hypertension in heartfailure with preserved ejection fraction: a target of phosphodiesterase-5 inhibitionin 1-year study. Even if thedominant negative effect is obviously expected to be bene?cial for tumor progression,it is worth noting that the ability of mutant p53 to promote tumor aggressiveness wasdemonstrated in elegant in vivo models for bona?de GOF lacking wt p53 [ 3]

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A shortcoming of register data is the lack of surgery-relatedrisk factors, such as duration of surgery or timing of antibiotic prophylaxis [77, 78].
 
 
 

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